Regu®-Fade (Resveratrol)

Regu®-Fade (Resveratrol)

Considered to be the molecule of eternal youth, resveratrol is an anti-oxidant with surprising effects: it delays aging and prevents disease. Its reparative powers have attracted the attention of the cosmetics sector.

Resveratrol is a naturally occurring ingredient mainly found in red grape skin. It is also found in peanuts and in berries such as blueberries, cranberries and bilberries; some pine trees; and the roots and stalks of giant knotweed and Japanese knotweed.


In nature, resveratrol functions as part of a plant’s defensive arsenal. Resveratrol is an antimicrobial substance produced by plants in response to stress, infection, or strong UV radiation. In recent years, resveratrol in particular has become the subject of intense interest due to its powerful antioxidant and anti-aging properties.

In a recent study, the antioxidant strength of 1% resveratrol was compared to that of 1% idebenone. Idebenone is a powerful pharmaceutical antioxidant. Its benefits include shielding the skin from environmental damage, improving the appearance of fine lines and wrinkles, reducing dryness, and smoothing skin texture. The results of the study revealed that resveratrol had a 17-fold greater antioxidant capacity than idebenone

Topical application of resveratrol to protect against UVB-mediated skin damage as well as inhibit UVB-induced oxidative stress has been observed in a number of additional studies. It has also been shown to prevent UVA damage and abnormal cellular proliferation.

Resveratrol is also able to form soluble, complex molecules with certain metal ions, inactivating the ions so they cannot produce free radical formation. This action, in combination with its powerful antioxidant capability, makes resveratrol highly effective in combating the damaging effect of free radicals that leads to skin aging. The antioxidant ability of resveratrol is known to be both potent and efficient. In fact, it has been shown to be greater than that of vitamins E and C. One study demonstrated that resveratrol was 95% efficient at preventing lipid peroxidation, compared to 65% for vitamin E and 37% for vitamin C.

Resveratrol is also reported to stimulate healthy cell proliferation as well as collagen synthesis by protecting the dermal matrix from harmful enzymes and improving the function of fibroblasts that create healthy collagen. This phenomenon reduces wrinkles and fine lines for an anti-aging effect. Anti-inflammatory and skin-brightening effects have also been associated with resveratrol.

The benefits of resveratrol have been limited by the instability of natural resveratrol’s short duration of efficacy. For this reason Complexi-Light research team decided to incorporate Regu-Fade in to the formulation. Regu-Fade was launched by DSM at InCosmetics in Milan and has been shown efficacy during in-vivo testing. This nature identical pure trans-resveratrol, which is free from pesticides addressing consumer awareness about safety and visible effects, focuses on skin lightening. Regu-Fade is said to both even and brighten skin tone using pure, nature-identical resveratrol.

Regu®-Fade (Resveratrol) 1

Regu-Fade is high performing and fast acting. It has proven its outstanding efficacy in only two weeks. Compared with a market benchmark, Regu-Fade worked faster early on and reduced the production of melanin more effectively throughout the studies.

DSM company has found that the resveratrol active attenuates skin pigmentation via multiple mechanisms, from initial signaling, gene expression to melanin production and final melanosome transfer.

  1. alpha-MSH signaling:

Regu-Fade down-regulates the alpha-MSH receptor expression to 49% in melanocytes, leading to decreased expression of tyrosinase, which reduces melanin synthesis.

  1. KIT signaling:

Regu-Fade decreases KIT (stem cell factor receptor) gene expression to 58% in melanocytes, which additionally reduces melanin synthesis.

  1. Melanosome function and maturation:

Regu-Fade also affects the function and maturation of melanosomes by reducing gene expression levels as much as 74%.

  1. Melanosome transport:

Regu-fade attenuates melanosome transport within melanocytes by reducing gene expression levels by as much as 69%. Melanosome transport to keratinocytes has shown to be reduced by the reduction of gene expression levels by 24%.

  1. Regu-Fade reduces the conversion of tyrosinase into eumelanin or pheomelanin shown by down-regulation of tyrosinase gene expression levels by 31% and other gene expression levels by as much as 85%.

Regu®-Fade (Resveratrol) 2

in vivo

The active reportedly down regulates key steps of melanin biosynthesis in vitro, resulting in brighter, younger-looking skin. In human trials conducted by the company, the resveratrol active was found to work faster and more effectively reduce melanin production compared with the market benchmark.

Regarding skin brightening, while some research has suggested that resveratrol is able to down regulate key steps in melanin production. Meanwhile, others have found that the ingredient inhibits the expression of inflammatory enzymes and promotes collagen synthesis.

Sirtuins have been the recently been associated and linked with resveratrol. Sirtuins are thought to extend the life of mitochondria, thereby preventing cellular damage. Resveratrol may activate sirtuins, so it may also have an anti-aging effect that extends beyond its antioxidant and collagen-promoting benefits.

In another study resveratrol has been shown to be more effective than ascorbic acid and kojicacid to lighten skin. It is fast acting with visible and significant results in only 2 weeks. In the same study it was found to reduce the appearance of aging skin due to its good antioxidant effects.

According to a small study published in the American Journal of Clinical Dermatology, resveratrol may be beneficial for treating acne too. Participants who applied a gel containing resveratrol to one side of their face and a placebo cream to the other showed a 66.7% reduction in acne lesions on the resveratrol side.